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KMID : 0356919940270111639
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Korean Journal of Anesthesiology
1994 Volume.27 No. 11 p.1639 ~ p.1645
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Comparative Study of Ondansetron versus Droperidol versus Placebo to Prevent Postoperative Nausea and Vomiting after Strabismus Surgery in Children
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이창현
이준학/이기남/문준일
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Abstract
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Postoperative nausea and vomiting is a troublesome problem in pediatric patients undergoing strabismus surgery. We compared the effects of ondansetron with those of droperidol and lacebo within the 24hrs postoperative period. 54 children, who
admitted
to Presbyterian Medical Center to receive strabismus operations, with ASA physical status 1, were assigned to one of three groups according to uncontrolled parallel comparative study design. A standard anesthetic technique consisting of
thiopental-vecuronium for induction and N2O-O2-enflurane for manitenance of anesthesia was used. The data showed that ondansetron 0.067mg/kg i.v. before induction was significantly more effective in preventing emesis (n=19m 100%) than placebo
(n=17,
58.8%). But, there was no significant difference between droperidol group and placebo group.
In conclusion, ondansetron (0.067mg/kg) given intravenously before induction to prevent postoperative nausea and vomiting in patients undergoing elective strabismus surgery in children was effective.
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